Medical Research Clinical Studies the
Benefits of
Tongkat ali in
Treating Erectile Dysfunction & Impotence
The following medical research studies document the benefits of Tongkat ali
in helping erectile dysfunction and impotence problems. These
health studies
are published on the website
http://www.ncbi.nlm.nih.gov of the National Library of Medicine,
National Institutes of Health,
U.S. Public Health Service.
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Tongkat
Ali
Review by Dr. Simon Chua,
Department of Pharmaceutical Sciences, Wayne State University,
USA.
In a
preliminary study at the Reproductive Research Center in Kuala Lumpur,
Malaysia, 30 married men, aged 31-52 years old, took
Tongkat Ali regularly
for three consecutive weeks. Interviews indicated that 48% felt healthy,
active and energized, and 40% felt increased
sexual desire. The subjects
showed an increased free testosterone index. Increased testosterone levels
help improve libido, energy and
muscle mass for body building. Their levels
of DHEA, another critical steroid hormone, gradually increased from 26%
after one week to
47% after three weeks. Most subjects demonstrated
increased satisfaction in their sexual health and performance. In addition,
animal
studies have shown that Tongkat Ali may increase testosterone
availability as well as libido in mice (Source: Article from the book
Molecular Biology of the Cell, published on Sept. 1, 2002).
Ang HH,
Cheang HS,
Yusof AP.
School of Pharmaceutical Sciences, University Science Malaysia, Penang,
Malaysia, as reported in
Exp
Anim. 2000 Jan;49(1):35- 8.
We studied the effects of Eurycoma longifolia Jack, commonly known as
Tongkat Ali in Malaysia, on the initiation of sexual performance
and the
weights of sexual accessories in inexperienced castrated male rats.The
doses of 200, 400 and 800 mg/kg body weight, which were
extracted from E. longifolia Jack, were orally administered to the rats twice daily for 10
days prior to the tests and continued throughout the
test period.
Testosterone was used as a positive control after injecting 15 mg/kg daily subcutaneously for 32 days. Results showed that E.
longifolia Jack produced
a dose-dependent increase in sexual performance of the treated animals, but
the E. longifolia Jack groups showed
lower sexual performance in mounting,
intromission and ejaculation than the testosterone group. Further results
also showed that E.
longifolia Jack promoted the growth of both ventral
prostate and seminal vesicles as compared with the control, but the growth
of sexual
accessories at 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack was less than that of
testosterone
treated group. The present study therefore gives further evidence of the folkuse of E. longifolia as an aphrodisiac.
PMID: 10803359 [PubMed - indexed for MEDLINE]
Evaluation of
the potency activity of aphrodisiac in Eurycoma longifolia Jack.
►Ang HH,
►Ikeda S,
►Gan EK.
School of Pharmaceutical
Sciences, University Science Malaysia, Minden, 11800, Penang, Malaysia.hhang@usm.my, as reported
in
Phytother Res. 2001 Aug;15(5):435-6.
The butanol, methanol, water
and chloroform extracts of the roots of Eurycoma longifolia Jack were
studied using various tests of potency
of treated male rats. The results
showed that E. longifolia produced a dose-dependent, recurrent
and significant increase
in the episodes of
penile reflexes as evidenced by increases in
quick flips, long flips and erections of the treated male rats
during the 30 min observation
period. These results provide further evidence
that E. longifolia increases the aphrodisiac potency activity in treated
animals. Copyright
2001 John Wiley & Sons, Ltd.
PMID: 11507738 [PubMed - indexed
for MEDLINE]
Eurycoma
longifolia Jack enhances libido in sexually experienced male rats.
►Ang HH,
►Sim MK.
School of Pharmaceutical
Sciences, University of Science Malaysia, Penang, Malaysia, as reported
in
Exp Anim. 1997 Oct;46(4):287-90.
The effects of Eurycoma longifolia Jack were studied on the libido of
sexually experienced male rats after dosing them with 200, 400 and
800 mg/kg body weight twice daily of different fractions of E. longifolia Jack for 10 days. Results showed that E.
longifolia Jack produced
a dose-dependent increase in mounting frequency
of the treated animals with 400 mg/kg of chloroform, methanol, water and butanol
fractions resulting in mounting frequencies of
5.3 +/- 1.2, 4.9 +/- 0.7, 4.8 +/- 0.7 and 5.2 +/- 0.1,
and 800 mg/kg further increased them
to 5.4 +/- 0.8, 5.4 +/- 0.8, 5.2 +/-
0.6 and 5.3 +/- 0.2 respectively but there were no erections, intromissions, ejaculations or seminal
emissions during the
20-min observation period which allowed for the
measurement of sexual arousal reflected by mounting frequency
uninfluenced
by other behavioural components. This study
provides evidence that E. longifolia Jack is a potent stimulator of sexual
arousal
in sexually vigorous male rats in the absence of feedback from genital sensation.
PMID: 9353636 [PubMed - indexed for
MEDLINE]
Effects of
Eurycoma longifolia Jack on sexual qualities in middle aged male rats.
►Ang HH,
►Ngai TH,
►Tan TH.
School of Pharmaceutical
Sciences, University Science Malaysia, Minden, Penang, Malaysia.hhang@usm.my, as reported in
Phytomedicine.
2003;10(6-7):590-3.
The effects of Eurycoma
longifolia Jack were studied on the sexual qualities of middle aged male
rats after dosing them with 0.5 g/kg of
various fractions of E. longifolia
whilst the control group received 3 ml/kg of normal saline daily for 12
weeks. Results showed than E.
longifolia Jack enhanced the sexual qualities
of the middle aged male rats by decreasing their hesitation time as compared
to controls with
various fractions of E. longifolia Jack produced 865-916
(91-96), 860-914 (92-98), 850-904 (93-99), 854-890 (95-99), 844-880(94-
98), 840-875 (94-98), 830-870 (94-98), 825-860
(94-98), 820-850 (96-99), 800-840 (93- 98), 750-795
(94-99) and 650-754 sec
(82-95%) in contrast to controls
which produced 950 (100), 934 (100), 910 (100), 900 (100), 895 (100), 890
(100), 885 (100), 880
(100), 855 (100), 860 (100), 800 (100) and 790 sec
(100%) throughout the investigation period. Besides these, there was a
transient
increase in the % of the male rats responding to the right choice
after chronic administration of 0.5 g/kg E. longifolia Jack, with more than
50%
of the male rats scored right choice after 2 weeks post- treatment and the effect was more
prominent at the dose of the observation
period.
However, there was no sexual enhancement of the middle aged male rats which
consumed normal saline since only 45-55% of the
male rats responded to right
choice throughout the investigation period. Hence, this study shows that E. longifolia Jack enhanced the sexual
qualities of the middle aged male rats, further supports the folkuse of E. longifolia Jack as an aphrodisiac.
PMID: 13678248 [PubMed - indexed
for MEDLINE]
Aphrodisiac
evaluation in non-copulator male rats after chronic administration of
Eurycoma longifolia Jack.
►Ang HH,
►Ngai TH.
School of Pharmaceutical
Sciences, University of Science Malaysia, Minden, 11800, Penang, Malaysia,
as reported in
Fundam Clin
Pharmacol. 2001 Aug;15(4):265-8.
The aphrodisiac effect of
Eurycoma longifolia Jack (0.5 g/kg) was evaluated in noncopulator male rats
using an electrical cage. Fractions of
E. longifolia Jack decreased the
hesitation time of noncopulator male rats, throughout the investigation
period. Furthermore, it possessed a
transient increase in the percentage of
the male rats responding to the right choice, more than 50% of the male rats
scored "right choice"
after 3 weeks post-treatment and the effect
became more prominent after 8 weeks post- treatment (only 40-50% of the
control male
rats
responded to the right choice) using the electrical copulation cage.
Hence, this study lends further support to the use of the plant by
indigenous populations as a traditional medicine for its aphrodisiac property.
PMID: 11564133 [PubMed - indexed
for MEDLINE]
Effects of
Eurycoma longifolia jack on laevator ani muscle in both uncastrated and
testosterone-stimulated castrated
intact male rats.
►Ang HH,
►Cheang HS.
School of Pharmaceutical
Sciences, University Science Malaysia, Minden, 11800, Penang, Malaysia. hhang@usm.my, as reported in
Arch
Pharm Res. 2001 Oct;24(5):437-40
It has been reported that
Eurycoma longifolia Jack commonly known as Tongkat Ali has gained notoreity
as a symbol of man's ego and
strength by the Malaysian men because it
increases male virility and sexual prowess during sexual activities. As
such, the effects of 200, 400
and 800 mg/kg of butanol, methanol, water and
chloroform fractions of E. longifolia Jack were studied on the laevator ani
muscle in both
uncastrated and testosterone-stimulated castrated intact male
rats after dosing them for 12 consecutive weeks. Results showed that 800
mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia
Jack significantly increased (p<0.05) the leavator ani muscle to
58.56+/-1.22, 58.23+/-0.31, 60.21 +/-0.86 and 62.35 +/-0.98 mg/100 g body
weight, respectively, when compared with the control
(untreated) in the uncastrated intact male rats and 49.23+/-0.82, 52.23+/-0.36, 50.21+/-0.66
and 52.35+/-0.58 mg/100 g body weight,
respectively, when compared to
control (untreated) in the testosterone- stimulated castrated intact
male
rats. Hence, the pro-androgenic
effect as shown by this study further
supported the traditional use of this plant as an aphrodisiac.
PMID: 11693547 [PubMed - indexed
for MEDLINE]
Sexual arousal
in sexually sluggish old male rats after oral administration of Eurycoma
longifolia Jack.
►Ang HH,
►Lee KL,
►Kiyoshi M.
School of Pharmaceutical
Sciences, University Science Malaysia, Minden, Penang, Malaysia.hhang@usm.my, as reported in
Basic
Clin Physiol Pharmacol. 2004;15(3-4):303-9.
Eurycoma longifolia Jack
commonly known as Tongkat Ali in Malaysia, has been used in Malaysia to
increase male virility and sexual
prowess. The objective of this study is to
evaluate sexual arousal in sexually sluggish old male rats, 24 months old
and
retired breeders,
receiving 200, 400, or 800 mg/kg of various fractions
of E. longifolia Jack, twice daily, for 10 days. Control rats received 3
ml/kg of
normal saline. The aphrodisiac effect was monitored by the act of
yawning and stretching because yawning, either alone or associated with
stretching, is considered an ancestral vestige surviving throughout
evolution that promotes sexual arousal. The results showed that 800
mg/kg of
E. longifolia Jack increased yawning by 50% and stretching by 16.7% in
sexually sluggish old male rats, by 676-719% and 31-
336%, respectively, in
sexually active male rats, and by 22-44% and 75-100%, respectively, in
middle aged, 9 months old and retired
breeders. We conclude that the results
of this study support the folk use of this plant as an aphrodisiac.
PMID: 15803965 [PubMed - indexed
for MEDLINE]
Tongkat ali is also effective
against germs
Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal
plant.Saudi Med J. 2007 Sep;28(9):1422-1424. Farouk AE,
Benafri A. Biomolecular
Engineering Research Unit, Department of Biotechnology Engineering, Kulliyyah of Engineering, International
Islamic University Malaysia, Jalan
Gombak, 53100, Kuala Lumpur, Malaysia.To evaluate methanolic, ethanolic, acetone and aqueous
extracts from
different parts of tongkat ali (leave, stem, and root) for antibacterial
activity against Gram- positive and Gram-negative
bacteria and to
utilize the leaves and stem parts rather than the root,
which is already used for male sexual enhancement in Malaysia. The
alcoholic and acetone extracts from
leaves and stems of tongkat alli contain potent antibacterial agent(s). This
plant can serve as a potential
source of antibacterial compounds.
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